Potassium Carbonate → 7-[(5-sec-butyl-1,3-thiazol-2-yl)thio]-4-(4-fluorophenyl)-2H-chromen-2-one
Reaktionsgleichung
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[CH:20]([C:24]1[S:28][C:27]([SH:29])=[N:26][CH:25]=1)([CH2:22][CH3:23])[CH3:21].C([O-])([O-])=O.[K+].[K+]>>[CH:20]([C:24]1[S:28][C:27]([S:29][C:2]2[CH:11]=[C:10]3[C:5]([C:6]([C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=4)=[CH:7][C:8](=[O:12])[O:9]3)=[CH:4][CH:3]=2)=[N:26][CH:25]=1)([CH2:22][CH3:23])[CH3:21]Komponenten
4
Versuchsvorschrift
Employing the procedure described in Example 1, Step 3, but using 7-bromo-4-(4-fluorophenyl)-2H-chromen-2-one, 5-sec-butyl-1,3-thiazole-2-thiol and K2CO3, the title compound was obtained. 1H NMR (400 MHz, acetone-d6): δ 7.58-7.67 (m, 3H), 7.52 (d, 1H), 7.46 (d, 1H), 7.32-7.42 (m, 3H), 6.38 (s, 1H), 3.08 (sextet, 1H), 1.83-1.67 (m, 2H), 1.32 (d, 3H), 0.89 (t, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-5b626d9762e24381907719c5f92282fa
- Quelldatensatz
- uspto-grants-2008_10
- Patentnummer
- US07439260B2
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