HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → Tolterodine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate | HCID 9847786 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | Tolterodine | HCID 443879 | — |
Reaktionsschritte
Tolterodine tartrate (2.1 g) is mixed with water (45 ml) and toluene (2.5 ml). Sodium carbonate (800 mg) is added to the slurry. Sodium hydroxide (2.0 N, 1.5 ml) is added. The mixture is extracted three times with toluene (3 ml), saving the organic phase. Anhydrous potassium carbonate is added to the organic phase dissolve the tolterodine tartate, giving the title compound in solution.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07439397B2 |
| Quelldatensatz | uspto-grants-2008_10 |
| ORD ID | ord-00454ea3d27d4de6ae950ba71adb20fc |
| Quellennotiz | uspto-grants-2008_10 |