2-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine → [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine	HCID 53471483	—
Edukt	5-Methylsulfonyl-2-[((R)-2,2,2-trifluoro-1-methylethyl)oxy]benzoic acid	HCID 58863354	—
Produkt	[5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-methanone	HCID 58677892	—

Reaktionsschritte

Prepared in analogy to example 1.1 from 2-trifluoromethyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine (CA [74737-17-7]; WO2004069162) and 5-methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.3). MS (m/e): 498.4 (M+H+).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07442710B2
Quelldatensatz	uspto-grants-2008_10
ORD ID	ord-c7c49c80504447dd94748d94fe7f08bc
Quellennotiz	uspto-grants-2008_10