6-Chloro-1,2,3,4-tetrahydroisoquinoline → (6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.[CH:12]1([CH2:15][O:16][C:17]2[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:18]=2[C:19](O)=[O:20])[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:19]([C:18]1[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:17]=1[O:16][CH2:15][CH:12]1[CH2:14][CH2:13]1)=[O:20])[CH2:6][CH2:5]2Komponenten
3
Versuchsvorschrift
Prepared in analogy to example 1.1 from 6-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [33537-99-4]) and 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (example 2.9). MS (m/e): 420.1 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-d5327d38697e48b7a0a2dee2e55c14d3
- Quelldatensatz
- uspto-grants-2008_10