4-(Pyridin-3-yl)benzaldehyde → 3-{3-[(4-Pyridin-3-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

HRID 2117497

Reaktionsgleichung

Reaktionsgleichung von HRID 2117497
Cl.[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH2:14])[CH:8]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)[CH:17]=1>>[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][CH2:26][C:25]2[CH:24]=[CH:23][C:22]([C:18]3[CH:17]=[N:16][CH:21]=[CH:20][CH:19]=3)=[CH:29][CH:28]=2)[CH:8]=1

Komponenten

3

Edukt 2

HCID 36930464-(Pyridin-3-yl)benzaldehydeHCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

Produkt 1

HCID 542431953-{3-[(4-Pyridin-3-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

Versuchsvorschrift

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and 4-pyridin-3-yl-benzaldehyde, of Preparation 23, using the method described in Example 1, Step A. 1H NMR (400 MHz, CDCl3) δ 8.79 (s, 1H), 8.55 (m, 1H), 7.81 (d, 1H), 7.53 (d, 2H), 7.46 (d, 2H), 7.32 (m, 1H), 7.22 (m, 3H), 7.09 (d, 1H), 3.84 (s, 2H), 3.80 (s, 2H), 3.63 (s, 3H), 2.92 (t, 2H), 2.61 (t, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-49f16adbc8014c7da7f7b3e9089a056e
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07442702B2

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