Nitric Acid → 1H-Imidazole, 4-methyl-5-nitro-

HRID 2118542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2118542
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[N+:7]([O-])([OH:9])=[O:8].S(=O)(=O)(O)O>>[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[N+:7]([O-:9])=[O:8]

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178418800HCID 178418800, Verbindung

Produkt 1

HCID 862781031H-Imidazole, 4-methyl-5-nitro-Ausbeute 41,6 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

4-Methylimidazole (10 g, 0.12 moles), was cooled in a flask, and fuming nitric acid (11 ml, 0.24 moles) was added dropwise. This was followed by the addition of sulfuric acid (11 ml). The reaction was then heated with stirring at 100° C. for 21/2 hours. The cooled reaction mixture was then added to 500 ml of ice water, and the precipitate was filtered off. The filtrate was neutralized with ammonium hydroxide, and filtered again. The combined precipitates were then recrystallized from water to give 6.35 g of 4-methyl-5-nitroimidazole.

Aufarbeitung

  1. temperatureThe reaction was then heated
  2. customThe cooled reaction mixture
  3. filtrationthe precipitate was filtered off
  4. filtrationfiltered again
  5. customThe combined precipitates
  6. customwere then recrystallized from water

Quellen und Nachweise

ORD-Eintrag
ord-1047adf5abe64db5a19761ff3104dd6d
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04678799

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