Reaktionsgleichung
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.[Cl:9][CH2:10][C:11](=[O:13])[CH3:12]>>[Cl-:9].[C:11]([CH2:12][N+:6]1[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=1)(=[O:13])[CH3:10]Komponenten
3
Versuchsvorschrift
The starting material may be prepared as follows: Reaction of 4-methylthiopyridine with 5 equivalents of chloroacetone at 40°-50° for 18 hours gave 1-acetylmethyl-4-methylthiopyridinium chloride. n.m.r. in solvent B: 2.27(s, 3H); 2.71(s, 3H); 6.0(s, 2H); 7.93(d, 2H); 8.5(d, 2H). Oxidation of this compound with a slight excess of metachlorpenbenzoic acid in CH2Cl2 /TFA at 0° to ambient temperature gave 1-acetylmethyl-4-methanesulphinyl pyridinium chloride. n.m.r. in solvent B: 2.32(s, 3H); 3.01(s, 3H); 5.84(s, 8.5(d, 2H); 9.0(d, 2H).
Aufarbeitung
- customThe starting material may be prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-c993378bd2214f8bab379773b09ff159
- Quelldatensatz
- uspto-grants-1987_07
- Patentnummer
- US04678781
Verknüpfte Notizen
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