2-Bromo-2'-chloroacetophenone → {3-[5-(2-Chloro-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([N:14]=[CH:15]N(C)C)=[S:13])([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:30]=[CH:29][CH:28]=[CH:27][C:22]=1[C:23](=[O:26])[CH2:24]Br>>[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:24]([C:23](=[O:26])[C:22]2[CH:27]=[CH:28][CH:29]=[CH:30][C:21]=2[Cl:20])=[CH:15][N:14]=1)([CH3:2])([CH3:3])[CH3:4]Komponenten
3
Versuchsvorschrift
The title compound was synthesised from [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic acid tert-butyl ester and 2-chloro phenacylbromide (commercially available) according to the procedure described for Example 25. MS (m/e): 395.8 (MH+, 100%).
Quellen und Nachweise
- ORD-Eintrag
- ord-c88ee0b9e7394a2686403778056b6f1a
- Quelldatensatz
- uspto-grants-2004_02