Trifluoroacetic acid → HCID 23442300, Verbindung
Reaktionsgleichung
[CH3:1][N:2]1[C:14]2[C:13](=[O:15])[C:12]3[CH:11]=[C:10]([CH3:16])[CH:9]=[CH:8][C:7]=3[N:6]([CH:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[C:5]=2[CH:4]=[N:3]1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][N:2]1[C:14]2[C:13](=[O:15])[C:12]3[CH:11]=[C:10]([CH3:16])[CH:9]=[CH:8][C:7]=3[N:6]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[C:5]=2[CH:4]=[N:3]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 45 °C
Versuchsvorschrift
To a solution of tert-butyl 4-(1,7-dimethyl-9-oxo-1,9-dihydro-4H-pyrazolo[4,3-b]quinolin-4-yl)-1-piperidinecarboxylate (EXAMPLE 64, step 1, 62 mg, 0.16 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (0.03 ml, 0.39 mmol) and the mixture was stirred at room temperature for 7 h and at 45° C. for 21 h. After evaporation, the residue was dissolved in dichloromethane (20 ml), washed with saturated aqueous sodium bicarbonate (20 ml) and dried over sodium sulfate. Removal of solvent gave 22 mg (47%) of the title compound as a white solid.