Nitric Acid → 6-Acetamido-3-butyl-5-nitro-phthalide

HRID 2120189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2120189
[N+:1]([O-:4])(O)=[O:2].[C:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]([CH2:19][CH2:20][CH2:21][CH3:22])[O:14][C:15]2=[O:16])=[CH:11][CH:10]=1)(=[O:7])[CH3:6]>>[C:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]([CH2:19][CH2:20][CH2:21][CH3:22])[O:14][C:15]2=[O:16])=[CH:11][C:10]=1[N+:1]([O-:4])=[O:2])(=[O:7])[CH3:6]

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 232747896-Acetamido-3-butyl-phthalide

Produkt 1

HCID 234391106-Acetamido-3-butyl-5-nitro-phthalide

Versuchsvorschrift

To 100 ml of stirred and ice-cold turning nitric acid (sp. gr. 1.50) there are added, in portions, 59 g (0.288 mol) of compound obtained in Example 7 with the temperature below 10° C. The resulting clear solution is put aside at room temperature overnight. The reaction material is poured into crushed ice, and the solid is filtered, washed with water, dried and crystallised from ethanol, giving the title compound.

Aufarbeitung

  1. additionThe reaction material is poured
  2. custominto crushed ice
  3. filtrationthe solid is filtered
  4. washwashed with water
  5. customdried
  6. customcrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-aae83b5e83bf44a2b51f533fcb26b36a
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06689808B2

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