Hydrochloride methanol → 4-Chloro-5-hydroxy-7-iodoisoindolinone

HRID 21261

Reaktionsgleichung

Reaktionsgleichung von HRID 21261
[Cl:1][C:2]1[C:10]([OH:11])=[CH:9][C:8]([I:12])=[C:7]2[C:3]=1[CH2:4][N:5](C(C)(C1C=CC=CC=1)C)[C:6]2=[O:13].Cl.CO>>[Cl:1][C:2]1[C:10]([OH:11])=[CH:9][C:8]([I:12])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:13]

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 684939844-Chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

Produkt 1

HCID 684892494-Chloro-5-hydroxy-7-iodoisoindolinoneAusbeute 58 %

Versuchsvorschrift

In a similar manner to Step 6 of Example 139, 4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (97.1 mg, 0.206 mmol) was treated with 10% hydrogen chloride-methanol solution (3 mL), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-hydroxy-7-iodoisoindolinone (36.9 mg, yield 58%).

Aufarbeitung

  1. customfollowed by purification by slurry

Quellen und Nachweise

ORD-Eintrag
ord-9e6bd2567c9c46e48a78b830e9111924
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745641B2

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