HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 215Erstellt: 23. Oktober 2026
4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline → (R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine
https://huagongshe.com/de/reaction/215
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline | HCID 44627476 | — |
| Edukt | (2R)-8-chloro-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepine | HCID 57512880 | — |
| Reagenz | Cesium carbonate | HCID 10796 | — |
| Katalysator | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Katalysator | Palladium (II) acetate | HCID 4144353 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | (R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine | HCID 49819370 | 0% |
Reaktionsschritte
A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing PALLADIUM(II) ACETATE (0.409 mg, 1.82 µmol), XANTPHOS (1.053 mg, 1.82 µmol) and CESIUM CARBONATE (8.89 mg, 0.03 mmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwavwe apparatus for 1 h and analyzed by LCMS. No product.
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-221a1c88a71944db90ec733265031251 |
|---|
| Quellennotiz | 750 AstraZeneca ELN dataset |
|---|
