Ethyl Methacrylate → HCID 388455, Verbindung

HRID 215694

Reaktionsgleichung

Reaktionsgleichung von HRID 215694
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[C:11](OCC)(=[O:15])[C:12]([CH3:14])=[CH2:13]>COC(C)(C)C>[CH3:13][CH:12]1[CH2:14][N:6]2[C:2](=[N:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=32)[NH:1][C:11]1=[O:15]

Komponenten

4

Edukt 2

HCID 7343Ethyl MethacrylateHCID 136242-Aminobenzimidazole

Produkt 1

HCID 388455HCID 388455, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 15413tert-Butyl methyl etherLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

5.326 g (40 mmol) 2-aminobenzimidazole and 4.56 g (40 mmol) ethyl methacrylate were dissolved in 25 ml Proglyde DMM. The reactionmixture is heated to 130° C. The reaction is allowed to continue for 7 hours at 130° C. The reactionmixture is allowed to cool down to room temperature and is added to 250 ml tert-butyl methyl ether. The precipitated 3,4-dihydro-3-methyl-pyrimidino[1,2-a]benzimidazol-2(1H)-one was isolated by filtration and recrystallized from 1-methoxy-2-propanol. 2.7 g (33%) of 3,4-dihydro-3-methyl-pyrimidino[1,2-a]benzimidazol-2(1H)-one was isolated (m.p. >260° C.).

Aufarbeitung

  1. temperatureto cool down to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-2e2cf69afac3486a8889f1bfba064846
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08192918B2

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