2-Chloroethyl Isothiocyanate → ((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

HRID 215710

Reaktionsgleichung

Reaktionsgleichung von HRID 215710
[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[Cl:11][CH2:12][CH2:13][N:14]=[C:15]=[S:16]>O1CCOCC1>[ClH:11].[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:15]1[S:16][CH2:12][CH2:13][N:14]=1

Komponenten

4

Edukt 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 2800811(2,3-Dimethylphenyl)methanamine

Produkt 1

HCID 68955163((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochlorideAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

Aufarbeitung

  1. temperatureto cool
  2. customa solid precipitate that had formed
  3. filtrationwas collected by filtration
  4. washThe solid was rinsed with diethyl ether
  5. customwas dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ab661d7a8bcc4d6ba081a13baa6c3320
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193118B2

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