HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Carbon Tetrachloride → 7-Chloromethyl-4-(3-thienyl)coumarin
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Carbon Tetrachloride | HCID 5943 | — |
| Edukt | Hexamethylphosphorous triamide | HCID 15355 | — |
| Edukt | 7-Hydroxymethyl-4-(3-thienyl)coumarin | HCID 15780558 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 7-Chloromethyl-4-(3-thienyl)coumarin | HCID 15780559 | — |
Reaktionsschritte
To a solution of the alcohol from Step 1 (1.65 g) and hexamethylphosphorous triamide in 35 mL THF at 0° C. was added CCl4 (1.3 mL) and the mixture stirred for 30 min. The mixture was diluted with Et2O, filtered, concentrated and the residue chromatographed (30% EtOAc/hexane) to provide the title compound as a solid, m.p. 125°-127° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05424320 |
| Quelldatensatz | uspto-grants-1995_06 |
| ORD ID | ord-41bf4b14ae7e4194a8b652aa27b29dc4 |
| Quellennotiz | uspto-grants-1995_06 |