3-(Dimethylamino)phenol → HCID 58006189, Verbindung

HRID 215913

Reaktionsgleichung

Reaktionsgleichung von HRID 215913
[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[CH:5]=1)[CH3:3].Cl[CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14].C([O-])([O-])=O.[K+].[K+]>CS(C)=O.ClCCl>[CH3:1][N:2]([CH3:3])[C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14]

Komponenten

6

Edukt 3

HCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 758862-chloro-N,N-dimethylacetamide

Produkt 1

HCID 58006189HCID 58006189, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of 3-N,N-dimethylamino phenol (69) (3.43 g, 25 mmol) and 2-chloro N,N-dimethylacetamide (3.66 g, 30 mmol) in DMSO (30 mL) was added K2CO3 (6.7 g, 50 mmol) and the resulting suspension was stirred at room temperature for 16 h. The reaction was then diluted with dichloromethane (125 mL), and washed with water (2×100 mL), and brine (100 mL), and dried, and filtered, and the solvent was removed under vacuum. The crude product, Compound 70, was obtained as purple, thick oil that was used in the next step without additional purification.

Aufarbeitung

  1. washwashed with water (2×100 mL), and brine (100 mL)
  2. customdried
  3. filtrationfiltered
  4. customthe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8c0bde69592943d7a6750f0b57894054
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193203B2

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