Isopropyl iodide → 3-Isopropoxy-N,N-dimethylaniline

HRID 215928

Reaktionsgleichung

Reaktionsgleichung von HRID 215928
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C([O-])([O-])=O.[K+].[K+].I[CH:18]([CH3:20])[CH3:19]>CC(C)=O>[CH:18]([O:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[N:2]([CH3:10])[CH3:1])([CH3:20])[CH3:19]

Komponenten

5

Edukt 3

HCID 6362Isopropyl iodideHCID 74213-(Dimethylamino)phenolHCID 11430Potassium Carbonate

Produkt 1

HCID 580062633-Isopropoxy-N,N-dimethylaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 3-(dimethylamino)phenol (2.0 g, 14.60 mmol) in acetone (40.0 mL) were added K2CO3 (20.2 g, 146.0 mmol) and 2-iodopropane (2.20 mL, 21.90 mmol), and the reaction was refluxed for 18 h, then cooled to room temperature, and filtered through Celite. The solvent was removed under vacuum, and the residue was purified by silica gel chromatography using ethyl acetate (20%) and hexanes (80%) as eluent to produce Compound 135 as yellow oil.

Aufarbeitung

  1. temperaturethe reaction was refluxed for 18 h
  2. filtrationfiltered through Celite
  3. customThe solvent was removed under vacuum
  4. customthe residue was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-56a13a33a481464abc3dc54c25c3545e
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193203B2

Verknüpfte Notizen

Wird geladen…