Dimethyl Sulfate → 1-Benzyl 4-methyl 4-(2-oxoethyl)piperidine-1,4-dicarboxylate

HRID 215948

Reaktionsgleichung

Reaktionsgleichung von HRID 215948
O=[O+][O-].[CH2:4]([C:7]1([C:23]([O:25][CH3:26])=[O:24])[CH2:12][CH2:11][N:10]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[CH2:9][CH2:8]1)[CH:5]=C.S(OC)(OC)(=O)=[O:28].C(N(CC)CC)C>C(Cl)Cl>[O:28]=[CH:5][CH2:4][C:7]1([C:23]([O:25][CH3:26])=[O:24])[CH2:12][CH2:11][N:10]([C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:14])[CH2:9][CH2:8]1

Komponenten

6

Edukt 4

HCID 6497Dimethyl SulfateHCID 8471TriethylamineHCID 24823OzoneHCID 588931861-Benzyl 4-methyl 4-allylpiperidine-1,4-dicarboxylate

Produkt 1

HCID 588931821-Benzyl 4-methyl 4-(2-oxoethyl)piperidine-1,4-dicarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Ozone was passed through a solution of 1-benzyl 4-methyl 4-allylpiperidine-1,4-dicarboxylate (10.0 g, 0.0315 mol) in methylene chloride (200.0 mL) at −78° C. until the color of the solution turned to steel blue. The reaction mixture was flushed with an atmosphere of nitrogen. Then to the solution was added dimethyl sulfate (6.0 mL, 0.063 mol) followed by triethylamine (8.8 mL, 0.063 mol). The mixture was stirred at room temperature for overnight, and then concentrated. The residue was dissolved in ethyl acetate, and the resulting solution was washed with saturated NH4Cl solution, NaHCO3 (7.5%), brine, dried over Na2SO4, filtered and concentrated to give 1-benzyl 4-methyl 4-(2-oxoethyl)piperidine-1,4-dicarboxylate.

Aufarbeitung

  1. customThe reaction mixture was flushed with an atmosphere of nitrogen
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washthe resulting solution was washed with saturated NH4Cl solution, NaHCO3 (7.5%), brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9c088989e27043079fb8bfe344eb42fa
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193207B2

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