Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide → Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide

HRID 215965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 215965
[BrH:1].C([O:4][C:5](=O)[CH2:6][N:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=[NH:13])C>C(O)C>[BrH:1].[N:13]1[C:5](=[O:4])[CH2:6][N:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12

Komponenten

3

Edukt 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

Produkt 1

HCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 9 g (34.4 mmol) of (2-imino-2H-pyridin-1-yl)-acetic acid ethyl ester hydrobromide salt in 200 mL of ethanol is heated at reflux for 18 h. The reaction mixture is then cooled to room temperature and the precipitate is collected. The isolated solid is washed with ethanol to give the desired compound.

Aufarbeitung

  1. temperatureat reflux for 18 h
  2. customthe precipitate is collected
  3. washThe isolated solid is washed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4312b25132944418ae79d67d6590fecd
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193214B2

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