4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline → (R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing Pd2(dba)3 (0.833 mg, 0.91 µmol), 2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL (0.638 mg, 1.82 µmol) and Cs2CO3 (8.89 mg, 0.03 mmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwavwe apparatus for 1 h and analyzed by LCMS. No product.

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