4-Chloro-2-nitroanisole → 5-Chloro-2-methoxyaniline

HRID 2163200

Reaktionsgleichung

Reaktionsgleichung von HRID 2163200
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-])=O)[CH:3]=1>[Ni]>[NH2:10][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

Komponenten

3

Edukt 1

HCID 666314-Chloro-2-nitroanisole

Produkt 1

HCID 667635-Chloro-2-methoxyaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 935NickelKatalysator

Versuchsvorschrift

0.037 mol (7 g) of 4-chloro-2-nitroanisole is dissolved in 100 ml of absolute alcohol and 3 g of nickel prepared by the RANEY process are added. The solution is hydrogenated at atmospheric pressure and at room temperature while stirring. The catalyst is separated and then washed with two portions of 20 ml of boiling ethanol. The alcoholic solution is concentrated under reduced pressure; the 2-amino-4-chloroanisole crystallizes.

Aufarbeitung

  1. additionare added
  2. customis hydrogenated at atmospheric pressure and at room temperature
  3. customThe catalyst is separated
  4. washwashed with two portions of 20 ml of boiling ethanol
  5. concentrationThe alcoholic solution is concentrated under reduced pressure
  6. customthe 2-amino-4-chloroanisole crystallizes

Quellen und Nachweise

ORD-Eintrag
ord-c028b86f410243dba402322e62916b94
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04132786

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