9,9-Dimethyl-9,10-dihydroacridine → 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan

Beteiligte Stoffe

Reaktionsschritte

Reaction of 9,9-dimethylacridan, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN as a distillable oil, b.p. 160-180° C. at 0.15 mm Hg. in 11% yield. Conversion of the free base to the hydrochloride salt affords 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN HYDROCHLORIDE, m.p. 232.5-234.5° C. (dec.) (corr.), by trituration with hot benzene.

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