HCID 47149234, Verbindung → 1-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

HRID 216331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 216331
[CH3:1][Mg]Br.CON(C)[C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[N:15]2)=[N:10][CH:9]=1>O1CCCC1>[N:14]1([C:11]2[N:10]=[CH:9][C:8]([C:7](=[O:19])[CH3:1])=[CH:13][CH:12]=2)[CH:18]=[CH:17][CH:16]=[N:15]1

Komponenten

4

Edukt 2

HCID 47149234HCID 47149234, VerbindungHCID 178418573HCID 178418573, Verbindung

Produkt 1

HCID 591619701-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methylmagnesium bromide (3 M in tetrahydrofuran) (3.16 mL, 9.5 mmol) was added to a −78° C. solution of N-methoxy-N-methyl-6-(1H-pyrazol-1-yl)nicotinamide (2.0 g, 8.6 mmol) in tetrahydrofuran (10 mL). After stirring at ambient temperature overnight, the reaction mixture was quenched with brine and extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo to afford the title compound.

Aufarbeitung

  1. customthe reaction mixture was quenched with brine
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic extracts were dried (magnesium sulfate)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5d0799ced85c4737a9e4e275e5ff81a5
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193228B2

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