Methyl trifluoromethyl ketone → Benzyl 4,4,4-trifluoro-3-methylbut-2-enoate

HRID 216352Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 216352
[F:1][C:2]([F:7])([F:6])[C:3]([CH3:5])=O.C1(P(=[CH:27][C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:29])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([CH3:5])=[CH:27][C:28]([O:30][CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)=[O:29]

Komponenten

4

Edukt 2

HCID 9871Methyl trifluoromethyl ketoneHCID 3862746Benzyl 2-(triphenyl-lambda5-phosphanylidene)acetate

Produkt 1

HCID 66705445Benzyl 4,4,4-trifluoro-3-methylbut-2-enoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1,1,1-Trifluoroacetone (680 mg, 6.1 mmol) was added to an ambient temperature solution of benzyl (triphenylphosphoranylidene)acetate (2.5 g, 6.1 mmol) in methylene chloride (10 mL). After stirring in a sealed tube for 72 h, the reaction mixture was concentrated in vacuo. Chromatography over silica eluting with 0-20% ethyl acetate/hexane afforded benzyl 4,4,4-trifluoro-3-methylbut-2-enoate.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-787f6bbc5f2b4757878113bd726cbc64
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193228B2

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