Hydrochloric Acid → Methyl 4-bromo-alpha-hydroxybenzeneacetate

HRID 216414

Reaktionsgleichung

Reaktionsgleichung von HRID 216414
Cl.[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1.[CH3:14]O>>[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([O:10][CH3:14])=[O:9])=[CH:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 97930p-Bromomandelic acid

Produkt 1

HCID 14571696Methyl 4-bromo-alpha-hydroxybenzeneacetate

Versuchsvorschrift

Hydrogen chloride (4 M in 1,4-dioxane) (3 mL, 18 mmol) was added to an ambient temperature solution of 4-bromomandelic acid (5 g, 21.6 mmol) in methanol (50 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford methyl (4-bromophenyl)(hydroxy)acetate which was used in the subsequent step without further purification.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-533bddb034934f46ba8c10cbee45ebb7
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193228B2

Verknüpfte Notizen

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