Hydroxylamine, O-ethyl- → HCID 136017205, Verbindung

HRID 2164363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164363
[CH2:1]([NH:3][C:4](=[S:24])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][C:16](=[O:18])[C:15]([C:19](=O)[CH2:20][CH3:21])=[C:14]([OH:23])[CH2:13]2)=[CH:8][CH:7]=1)[CH3:2].[CH2:25]([O:27][NH2:28])[CH3:26]>C(Cl)(Cl)Cl>[CH2:25]([O:27][N:28]=[C:19]([C:15]1[C:16](=[O:18])[CH2:17][CH:12]([C:9]2[CH:8]=[CH:7][C:6]([NH:5][C:4]([NH:3][CH2:1][CH3:2])=[S:24])=[CH:11][CH:10]=2)[CH2:13][C:14]=1[OH:23])[CH2:20][CH3:21])[CH3:26]

Komponenten

4

Edukt 2

HCID 69357Hydroxylamine, O-ethyl-HCID 178465509HCID 178465509, Verbindung

Produkt 1

HCID 136017205HCID 136017205, VerbindungAusbeute 88,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Into 10 ml of chloroform was dissolved 1.4 g of 5-{4-[3-(ethyl)thioureido]phenyl}-3-hydroxy-2-propionyl-2-cyclohexen-1-one and to the solution was added 1.0 g of ethoxyamine. The mixture was kept for 15 hours at room temperature and the reacting mixture was washed with a dilute hydrochloric acid solution and water. The solution was dried with anhydrous magnesium sulfate and the chloroform was distilled off from it under reduced pressure and 1.4 g of the desired compound was obtained. It was in the form of colorless crystals having a decomposition point of 116°-118° C.

Aufarbeitung

  1. washthe reacting mixture was washed with a dilute hydrochloric acid solution and water
  2. dry with materialThe solution was dried with anhydrous magnesium sulfate
  3. distillationthe chloroform was distilled off from it under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-47597b6b219548cda2eb5fdcbacec4ac
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04504305

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