Hydrochloric Acid → 2-Fluoro-6-(phenylamino)benzonitrile

HRID 2164448

Reaktionsgleichung

Reaktionsgleichung von HRID 2164448
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].Cl.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:3]=1[C:4]#[N:5]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 746952,6-Difluorobenzonitrile

Produkt 1

HCID 134697992-Fluoro-6-(phenylamino)benzonitrile

Versuchsvorschrift

A mixture of 2.8 g (20 mmol) of 2,6-difluorobenzonitrile in 20 ml of aniline is refluxed for 6 hrs. The mixture is poured into diluted HCl and the acid is extracted with methylene chloride. Evaporation gives the crude product which is chromatographed on silica gel (50% hexane--CH2Cl2) to give the title compound, m.p. 97°-99° C.

Aufarbeitung

  1. temperatureis refluxed for 6 hrs
  2. extractionthe acid is extracted with methylene chloride
  3. customEvaporation
  4. customgives the crude product which
  5. customis chromatographed on silica gel (50% hexane--CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-30c1ed890d374469b34a85c512485c68
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04504660

Verknüpfte Notizen

Wird geladen…