Sodium Hydroxide → N'-t-butyl-N-(2-pyridinecarbonyl)-N'-(3,4-dichlorobenzoyl)hydrazine

HRID 21648

Reaktionsgleichung

Reaktionsgleichung von HRID 21648
[C:1]([NH:5][NH:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:8])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].[Cl:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[Cl:27])[C:21](Cl)=[O:22]>C1(C)C=CC=CC=1>[C:1]([N:5]([C:21](=[O:22])[C:20]1[CH:24]=[CH:25][C:26]([Cl:27])=[C:18]([Cl:17])[CH:19]=1)[NH:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:8])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 76403Benzoyl chloride, 3,4-dichloro-HCID 15767542N'-t-butyl-N-(2-pyridinecarbonyl)hydrazine

Produkt 1

HCID 15767546N'-t-butyl-N-(2-pyridinecarbonyl)-N'-(3,4-dichlorobenzoyl)hydrazineAusbeute 79,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
23 °C

Versuchsvorschrift

A solution of N'-t-butyl-N-(2-pyridinecarbonyl)-hydrazine (0.5 g) in 10 ml of toluene was treated with 50% sodium hydroxide (0.61 g). 3,4-Dichlorobenzoyl chloride (0.6 g) was added and the mixture was stirred rapidly for 4 hours at 23° C. and then was allowed to stand for 48 hours. The solids were removed by filtration and washed with water to afford 0.75 g of N'-t-butyl-N-(2-pyridinecarbonyl)-N'-(3,4-dichlorobenzoyl)hydrazine as a white solid: m.p. 175°-178° C.

Aufarbeitung

  1. waitto stand for 48 hours
  2. customThe solids were removed by filtration
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-18c27fb958a94b719c536689407476d8
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424333

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