Thionyl Chloride → 2-(1-Chloroethyl)-1,3-benzothiazole

HRID 2165073Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2165073
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10](O)[CH3:11].S(Cl)([Cl:15])=O>C(Cl)Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([Cl:15])[CH3:11]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 28306741-(1,3-Benzothiazol-2-yl)ethan-1-ol

Produkt 1

HCID 109979582-(1-Chloroethyl)-1,3-benzothiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1-(2-benzothiazolyl)ethanol (2.5 g) prepared according to J. Indian Chem. Soc., 566 (1974) in methylene chloride (50 ml) was added thionyl chloride (3.32 g) and the resulting solution stirred at room temperature for 1 hour. The solution was poured onto ice-water (100 ml) and the organic extract separated. This extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml). The methylene chloride layer was dried over anhydrous magnesium sulfate and evaporated to a light yellow oil (2.08 g).

Aufarbeitung

  1. additionThe solution was poured onto ice-water (100 ml)
  2. extractionthe organic extract
  3. customseparated
  4. washThis extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml)
  5. dry with materialThe methylene chloride layer was dried over anhydrous magnesium sulfate
  6. customevaporated to a light yellow oil (2.08 g)

Quellen und Nachweise

ORD-Eintrag
ord-b7ea343a2c8946b4a3ba7c2e6a332844
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04939140

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