Benzaldehyde → 2-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-

HRID 2165128

Reaktionsgleichung

Reaktionsgleichung von HRID 2165128
[OH-].[Na+].[C:3]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>C(O)C>[CH3:11][C:8]1[S:7][C:6]([C:3](=[O:5])[CH:4]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:10][CH:9]=1

Komponenten

6

Edukt 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 836552-Acetyl-5-methylthiophene

Produkt 1

HCID 2386072-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-Ausbeute 67,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A stirred solution of 2.2 grams (0.055 mole) of sodium hydroxide in 20 ml of ethanol was cooled to 0° C. and a mixture of 4.0 grams (0.03 mole) of 2-acetyl-5-methylthiophene and 3.1 grams (0.03 mole) of benzaldehyde in 5 ml of ethanol was added dropwise. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it stirred for 16 hours. The reaction mixture was poured into aqueous 1N hydrochloric acid and extracted with methylene chloride. The extract was dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to yield 4.6 grams of 1-(5-methyl-2-thienyl)-3-phenyl-2-propen-1-one as a solid.

Aufarbeitung

  1. additionwas added dropwise
  2. additionUpon completion of addition the reaction mixture
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-70d25324e4b141e2a8305046095b2240
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04939165

Verknüpfte Notizen

Wird geladen…