Methyl iodide →

HRID 2165563Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2165563
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C@H:11]([C@H:13]2[NH:18][C:17](=[O:19])[C@@H:16]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=3)[NH:15][C:14]2=[O:27])[CH3:12])=[CH:3]1.[CH3:28][I:29]>>[I-:29].[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C@H:11]([C@H:13]2[NH:18][C:17](=[O:19])[C@@H:16]([CH2:20][CH2+:21]3[CH:26]=[CH:25][CH:24]=[CH:23][N:22]3[CH3:28])[NH:15][C:14]2=[O:27])[CH3:12])=[CH:3]1

Komponenten

2

Edukt 2

HCID 6328Methyl iodideHCID 14151964(3R,6R)-3-[(R)-1-(1-methylindol-3-yl)ethyl]-6-(2-pyridylmethyl)piperazine-2,5-dione

Produkt 0

Noch keine Daten: Produkt

Versuchsvorschrift

A mixture of (3R,6R)-3-[(R)-1-(1-methylindol-3-yl)ethyl]-6-(2-pyridylmethyl)piperazine-2,5-dione (0.10 g) and methyl iodide (5 ml) was stirred under reflux for 4 days. After evaporation of the excess methyl iodide, crude oily residue was washed with chloroform and ether, and dried in vacuo to give (3R,6R)-3-[(R)-1-(1-methylindol-3-yl)ethyl]-6-(1-methyl-2-pyridiniomethyl)piperazine-2,5-dione iodide as a solid (0.12 g).

Aufarbeitung

  1. temperatureunder reflux for 4 days
  2. customAfter evaporation of the excess methyl iodide
  3. washcrude oily residue was washed with chloroform and ether
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c5178b291adb44189f696d2354ed9a38
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04940709

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