7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 14839376, Verbindung

HRID 2165632Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2165632
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]2[CH2:12][NH:11][CH2:10][CH2:9][NH:8]2)[S:5][CH:6]=1.Cl[C:14]1[CH:23]=[C:22]2[C:17]([C:18](=[O:29])[C:19]([C:26]([OH:28])=[O:27])=[CH:20][N:21]2[CH2:24][CH3:25])=[CH:16][C:15]=1[F:30]>N1C=CC=CC=1>[CH2:24]([N:21]1[C:22]2[C:17](=[CH:16][C:15]([F:30])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH:7]([C:4]4[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=4)[CH2:12]3)[CH:23]=2)[C:18](=[O:29])[C:19]([C:26]([OH:28])=[O:27])=[CH:20]1)[CH3:25]

Komponenten

4

Edukt 2

HCID 4831697-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 197636002-(4-Methylthiophen-2-yl)piperazine

Produkt 1

HCID 14839376HCID 14839376, VerbindungAusbeute 24,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 10.92 g of 2-(4-methyl-2-thienyl)piperazine and 5.38 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 30 ml of pyridine was heated at reflux under argon for 18 hours, then allowed to cool and the solvent removed. The residue was triturated with methanol and ether, then filtered and dried, giving 2 g of the desired product, mp 230° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux under argon for 18 hours
  3. temperatureto cool
  4. customthe solvent removed
  5. customThe residue was triturated with methanol and ether
  6. filtrationfiltered
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f8917d294ae4444eb5429387adc69f93
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04940710

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