7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid → 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid	HCID 57338	—
Edukt	2-(Methoxymethyl)piperazine	HCID 14230264	—
Lösungsmittel	Pyridine	HCID 1049	—
Produkt	6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid	HCID 14839406	—

Reaktionsschritte

A 906 mg portion of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine were added to 10 ml of pyridine and reacted as described in Example 81, giving 187 mg of the desired product, mp 216°-218° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04940710
Quelldatensatz	uspto-grants-1990_07
ORD ID	ord-8125365767bf4ef0b61cfafca36f90ea
Quellennotiz	uspto-grants-1990_07