HCID 14990558, Verbindung → HCID 14990559, Verbindung

HRID 2166030Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166030
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:12]([N+:20]([O-])=O)[CH:11]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:20][C:12]1[CH:11]=[C:10]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:9])[CH:15]=[CH:14][C:13]=1[NH:16][CH:17]([CH3:18])[CH3:19]

Komponenten

5

Edukt 2

HCID 14990558HCID 14990558, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 14990559HCID 14990559, VerbindungAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 14.7 parts of (4-fluorophenyl) [4-[(1-methylethyl)amino]-3-nitrophenyl]methanone in 120 parts of ethanol was hydrogenated at 2.105Pa with 3 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated, yielding 12.3 parts (92.1%) of [3-amino-4-[(1-methylethyl)amino]phenyl](4-fluorophenyl)methanone as a residue (int. 2).

Aufarbeitung

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d6ffda214e844c3480bb33dc11040f14
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04943574

Notizen zur Reaktion

Wird geladen…