Methyl iodide → HCID 14405656, Verbindung

HRID 2166373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166373
[I:1][CH3:2].[N:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:5][CH:4]=1>C(OCC)(=O)C>[I-:1].[CH3:2][N+:3]1[CH:4]=[CH:5][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 4137929HCID 4137929, Verbindung

Produkt 1

HCID 14405656HCID 14405656, VerbindungAusbeute 86,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2 ml, equivalent to 4.26 g (30.2 mmol) of iodomethane and 6 g (25.2 mmol) of 2-[(4-pyridyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline are introduced into 200 ml of ethyl acetate, and the mixture is stirred for 24 h at room temperature. A yellow precipitate forms, which is filtered off and washed with ether. 8.3 g of product are obtained, this being used without further treatment in the following stage.

Aufarbeitung

  1. filtrationA yellow precipitate forms, which is filtered off
  2. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-0cebb6095cff473b886318f6ed940e4a
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04945096

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