Veratryl chloride → HCID 14499767, Verbindung

HRID 2166376Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166376
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10]2)=[O:8])=[CH:3][CH:2]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH2:24][Cl:25]>C(OCC)(=O)C>[Cl-:25].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:24][N+:1]2[CH:2]=[CH:3][C:4]([C:7]([N:9]3[CH2:18][CH2:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[CH2:10]3)=[O:8])=[CH:5][CH:6]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

Komponenten

4

Edukt 2

HCID 81740Veratryl chlorideHCID 4137929HCID 4137929, Verbindung

Produkt 1

HCID 14499767HCID 14499767, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 4.76 g (20 mmol) of 2-[(4-pyridyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline, 4.5 g (24 mmol) of 3,4-dimethoxybenzyl chloride and 200 ml of ethyl acetate is heated under reflux for 20 h. The mixture obtained is allowed to cool, and the precipitate is separated off by filtration and washed with ether. 6.6 g of salt are collected, this being used without further purification in the following stage.

Aufarbeitung

  1. temperatureis heated
  2. temperatureunder reflux for 20 h
  3. customThe mixture obtained
  4. temperatureto cool
  5. customthe precipitate is separated off by filtration
  6. washwashed with ether
  7. custom6.6 g of salt are collected
  8. customthis being used without further purification in the following stage

Quellen und Nachweise

ORD-Eintrag
ord-7acb3d3a9b834bdb9ed5864ba5631ab7
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04945096

Notizen zur Reaktion

Wird geladen…