Lactic Acid → 1-Carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

HRID 2166783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166783
[CH:1]1([CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20]([OH:25])(=[O:24])[CH:21]([CH3:23])O.C1(C)C(S(O)(=O)=O)=CC=CC=1>C1(C)C=CC=CC=1>[CH:1]1([CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19][CH:21]([C:20]([OH:25])=[O:24])[CH3:23])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 612Lactic AcidHCID 69252-Methylbenzenesulfonic acidHCID 204989854-(2-Cyclohexylethylamino)phenylacetic acid

Produkt 1

HCID 204989661-Carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A flask containing 10.0 g. 4-(2-cyclohexylethylamino)phenylacetic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate separates as off-white crystals.

Aufarbeitung

  1. additionA flask containing 10.0 g
  2. additioncharged
  3. temperatureThe solution is refluxed for 24 hours during which time the Soxhlet extractor
  4. additionis charged twice more with fresh sieves
  5. filtrationThe hot solution is filtered
  6. waitleft
  7. temperatureto cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

Quellen und Nachweise

ORD-Eintrag
ord-8d82bec79b614671baf3ccf1317ba36d
Quelldatensatz
uspto-grants-1983_06
Patentnummer
US04388459

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