HCID 20497520, Verbindung → Ethyl 4-(4-aminobutyl)piperazine-1-carboxylate

HRID 2166923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2166923
[C:1]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:8][CH2:7]1)#[N:2]>N.C(O)C.[Rh]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:10][CH2:11]1

Komponenten

5

Edukt 1

HCID 20497520HCID 20497520, Verbindung

Produkt 1

HCID 20497516Ethyl 4-(4-aminobutyl)piperazine-1-carboxylateAusbeute 32,7 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23948RhodiumKatalysatorHCID 222AmmoniaLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

60 g of ethyl 4-(3-cyanopropyl)-piperazine-1-carboxylate were dissolved in a 10% w/w solution of ammonia in ethanol and 6 g of 5% rhodium on alumina were added thereto. The mixture was cooled to room temperature and filtered. The filtrate was evaporated to dryness under vacuum and the residual oil was distilled under reduced pressure to obtain 20 g of ethyl 4-(4-aminobutyl)-piperazine-1-carboxylate with a boiling point of 126°-130° C. at 0.15 to 0.2 mm Hg.

Aufarbeitung

  1. additionwere added
  2. filtrationfiltered
  3. customThe filtrate was evaporated to dryness under vacuum
  4. distillationthe residual oil was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-febb1e1e9fd94a0aae15d11aa63c7d03
Quelldatensatz
uspto-grants-1983_06
Patentnummer
US04390697

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