2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221, Verbindung

HRID 2167684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2167684
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

Komponenten

5

Edukt 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

Produkt 1

HCID 44119221HCID 44119221, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Aufarbeitung

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-08b61626b11249f295c4aeb7010332f1
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09045477B2

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