Ethyl 3-aminocyclohexanecarboxylate → (3-Aminocyclohexyl)methanol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

LAH (107 mg, 2.8 mmol) was added portionwise to a solution of ethyl 3-aminocyclohexanecarboxylate (320 mg, 1.87 mmol) in THF (5 mL) at 0° C. and continued stirring at 25-30° C. for 15 h. The reaction mixture was quenched with aqueous saturated sodium sulphate solution, filtered the solid precipitate, washed the solid with THF; the filtrate collected was concentrated under reduced pressure to afford 200 mg of the title compound.

Herkunft & Nachweise