1H-1,2,4-Triazole → 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

HRID 2167796

Reaktionsgleichung

Reaktionsgleichung von HRID 2167796
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C([O-])([O-])=O.[K+].[K+]>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

Komponenten

4

Edukt 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 952642-Fluoro-5-nitropyridine

Produkt 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

2-fluoro-5-nitropyridine (30 g, 18.9 mmol) was added to a stirred solution of 1H-1,2,4-triazole (1.566 g, 22.7 mmol) and K2CO3 (5.14 g, 37.8 mmol) and stirred for 16 hrs at 25° C. Reaction mass was diluted with ice cold water and stirred for 15 min. The solid obtained was filtered and dried under vacuum to afford the desired product. MS (ESI): m/z 192 (M+H).

Aufarbeitung

  1. customReaction mass
  2. additionwas diluted with ice cold water
  3. stirringstirred for 15 min
  4. customThe solid obtained
  5. filtrationwas filtered
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fe1dabd14ff74e529d27d0fbafe163ee
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09045479B2

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