1-Butanol → HCID 178424622, Verbindung

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a stirred solution of (1S)-1-(8-chloro-2-(6-methylpyridin-2-yl)quinolin-3-yl)-ethanamine (146 mg, 0.49 mmol) in 1-butanol (5.4 mL, 59 mmol) was added 6-bromopurine (0.107 g, 0.54 mmol) and N,N-diisopropylethylamine (0.17 mL, 0.98 mmol) with heating (110° C.) overnight solvents were removed and the residue subjected to chromatography, gradient, 89:9:1 (DCM:MeOH:NH4OH). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.84 (1H, br. s.), 8.67 (1H, s), 8.38 (1H, br. s.), 8.03-8.10 (1H, m), 7.84-7.98 (5H, m), 7.56 (1H, t, J=7.8 Hz), 7.36 (1H, d, J=5.5 Hz), 6.03 (1H, br. s.), 2.58 (3H, br. s.), 1.66 (3H, d, J=6.3 Hz) Mass Spectrum (ESI) m/e=415.9 (M+1).

Herkunft & Nachweise