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Ethanol → 10,10-dimethyl-12-(10-(naphthalen-2-yl)anthracen-9-yl)-10H-indeno[1,2-b]triphenylene

HRID 2169686
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2169686
[CH3:1][C:2]1([CH3:36])[C:26]2[C:6]([CH:7]=[C:8]3[CH:25]=[C:24]4[C:11]([C:12]5[C:17]([C:18]6[C:23]4=[CH:22][CH:21]=[CH:20][CH:19]=6)=[CH:16][CH:15]=[CH:14][CH:13]=5)=[CH:10][C:9]3=2)=[CH:5][C:4](B2OC(C)(C)C(C)(C)O2)=[CH:3]1.Br[C:38]1[C:39]2[C:44]([C:45](C3C4C(=CC=CC=4)C(F)=CC=3)=[C:46]3[C:51]=1[CH:50]=[CH:49][CH:48]=[CH:47]3)=[CH:43][CH:42]=[CH:41][CH:40]=2.[C:63]([O-])([O-])=O.[Na+].[Na+].[CH2:69](O)[CH3:70].[C:72]1([CH3:78])[CH:77]=[CH:76][CH:75]=[CH:74][CH:73]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:36][C:2]1([CH3:1])[C:26]2[C:6]([CH:7]=[C:8]3[CH:25]=[C:24]4[C:11]([C:12]5[C:17]([C:18]6[C:23]4=[CH:22][CH:21]=[CH:20][CH:19]=6)=[CH:16][CH:15]=[CH:14][CH:13]=5)=[CH:10][C:9]3=2)=[CH:5][C:4]([C:38]2[C:39]3[C:44]([C:45]([C:70]4[CH:69]=[CH:63][C:77]5[C:72](=[CH:73][CH:74]=[CH:75][CH:76]=5)[CH:78]=4)=[C:46]4[C:51]=2[CH:50]=[CH:49][CH:48]=[CH:47]4)=[CH:43][CH:42]=[CH:41][CH:40]=3)=[CH:3]1
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Komponenten

7

Edukt 5

HCID 702EthanolHCID 1140TolueneHCID 10340Sodium CarbonateHCID 576946099-Bromo-10-(4-fluoronaphthalen-1-yl) anthraceneHCID 8671831210,10-dimethyl-(10H-indeno[1,2-b]triphenylen-12-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Produkt 1

HCID 86718313
10,10-dimethyl-12-(10-(naphthalen-2-yl)anthracen-9-yl)-10H-indeno[1,2-b]triphenylene
Ausbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418397HCID 178418397, VerbindungKatalysator

Versuchsvorschrift

A three-necked 250 mL flask was charged with 2-(10,10-dimethyl-10H-indeno[1,2-b]triphenylen-12-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (5.0 g, 10.6 mmol), 9-bromo-10-(4-fluoronaphthalen-1-yl) anthracene (4.26 g, 10.6 mmol), Pd(PPh3)4 (0.25 g, 0.21 mmol), aqueous Na2CO3 (2.0 M, 12 mL, 23.4 mmol), ethanol (15 mL), and toluene (50 mL). The mixture was degassed and refluxed for 24 h under a nitrogen atmosphere. After being cooled, H2O (50 mL) was added to the mixture. The crude product was collected as a yellow-green solid powder by filtration and washed with methanol several times to remove impurity. It was dried at 20° C. under vacuum and gave a bright yellow-green solid product in 85% yield (6.01 g, 9.0 mmol). MS (m/z, FAB+): 664.8 1H NMR (CDCl3, 400 MHz): chemical shift (ppm) 9.14 (s, 1H), 8.90 (d, J=7.80 Hz, 1H), 8.82 (d, J=7.92 Hz, 1H), 8.79 (s, 1H), 8.73 (d, J=7.88 Hz, 2H), 8.23 (d, J=7.72 Hz, 1H), 8.11 (d, J=8.24 Hz, 1H), 8.07˜8.02 (m, 2H), 7.96 (d, J=7.40 Hz, 1H), 7.89 (d, J=8.64 Hz, 2H), 7.78˜7.59 (m, 9H), 7.42˜7.28 (m, 4H), 7.20 (d, J=7.40 Hz, 1H), 1.76 (s, 6H).

Aufarbeitung

  1. customThe mixture was degassed
  2. temperaturerefluxed for 24 h under a nitrogen atmosphere
  3. temperatureAfter being cooled
  4. additionH2O (50 mL) was added to the mixture
  5. filtrationThe crude product was collected as a yellow-green solid powder by filtration
  6. washwashed with methanol several times
  7. customto remove impurity
  8. customIt was dried at 20° C. under vacuum
  9. customgave a bright yellow-green solid product in 85% yield (6.01 g, 9.0 mmol)

Quellen und Nachweise

ORD-Eintrag
ord-691b965e48d94cde9bd66bf434a18661
Quelldatensatz
uspto-grants-2015_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09048437B2

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