Phosphorus oxychloride → Ethyl 4-chloro-6-propoxyquinoline-3-carboxylate

HRID 2169846

Reaktionsgleichung

O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH2:13][CH2:14][CH3:15])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH2:13][CH2:14][CH3:15])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 178458202Ethyl 4-hydroxy-6-propoxyquinoline-3-carboxylate

Produkt 1

HCID 62328167Ethyl 4-chloro-6-propoxyquinoline-3-carboxylate

Versuchsvorschrift

Prepared as in Example 1b from ethyl 4-hydroxy-6-propoxyquinoline-3-carboxylate (Example 14c) and POCl3 as a pale yellow solid. MS 294, 296 (MH+).

Quellen und Nachweise

ORD-Eintrag: ord-8659bdf22b00406ea3cfb1700c19776f
Quelldatensatz: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09049878B2

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