Triethyl phosphite → Benzyl (diethoxyphosphoryl)acetate

HRID 2170517Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170517
[CH2:1]([O:8][C:9](=[O:12])[CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([O:15][P:16]([O:20]CC)[O:17][CH2:18][CH3:19])[CH3:14]>>[CH2:1]([O:8][C:9](=[O:12])[CH2:10][P:16]([O:17][CH2:18][CH3:19])([O:15][CH2:13][CH3:14])=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 31215Triethyl phosphiteHCID 62576Benzyl bromoacetate

Produkt 1

HCID 281239Benzyl (diethoxyphosphoryl)acetateAusbeute 80,3 %

Versuchsvorschrift

The mixture of bromo-acetic acid benzyl ester (229 g, 1.0 mol) and phosphorous acid triethyl ester (166 g, 1.0 mol) was stirred at reflux for 10 hrs and the solvent was evaporated in vacuo to give crude (diethoxy-phosphoryl)-acetic acid benzyl ester (230 g) which was directly used for next step.

Aufarbeitung

  1. temperatureat reflux for 10 hrs
  2. customthe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-74ab55953b9748ec8c6d2eb897d01782
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051280B2

Notizen zur Reaktion

Wird geladen…