Azobisisobutyronitrile → HCID 86674584, Verbindung

HRID 2170647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170647
[Cl:1][C:2]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:3]=1[O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7].C1C(=O)N([Br:23])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:23][CH2:15][C:12]1[CH:13]=[CH:14][C:2]([Cl:1])=[C:3]([CH:11]=1)[O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7]

Komponenten

5

Edukt 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 40647465HCID 40647465, Verbindung

Produkt 1

HCID 86674584HCID 86674584, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

To (S)-methyl 2-(2-chloro-5-methylphenoxy)propanoate (2.4 g, 10.5 mmol) in CCl4 (20 mL) was added NBS (1.92 g, 11.55 mmol) and AIBN (0.35 g, 2.1 mmol). The mixture was refluxed overnight. The reaction mixture was cooled and the solvent was removed to obtain the crude. The crude was purified by flash chromatography (AcOEt/Hexane 0˜30%) to obtain the title compound.

Aufarbeitung

  1. temperatureThe mixture was refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed
  4. customto obtain the crude
  5. customThe crude was purified by flash chromatography (AcOEt/Hexane 0˜30%)

Quellen und Nachweise

ORD-Eintrag
ord-238bd778d95249b58c745be1cd64de74
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051265B2

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