Hydrochloric Acid → MFCD18873289

HRID 2170850Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170850
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]C)=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 671694841H-Indole-5-carboxylic acid, 1-(2-methoxyethyl)-, methyl ester

Produkt 1

HCID 63750378MFCD18873289Ausbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of methyl 1-(2-methoxyethyl)-1H-indole-5-carboxylate (132 mg, 0.57 mmol, Step-1), 2M aqueous sodium hydroxide solution (2 mL), and methanol (2 mL) was stirred at 60° C. for 2 hours. The mixture was acidified with 2M aqueous hydrochloric acid solution, and the organic solvent was concentrated under reduced pressure. The precipitate was collected by filtration and dried to give 118 mg (95%) of the title compound as a white solid.

Aufarbeitung

  1. concentrationthe organic solvent was concentrated under reduced pressure
  2. filtrationThe precipitate was collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9d1f213d501747d5a0db55da64284643
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051296B2

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