Isopropyl chloroformate → HCID 54577375, Verbindung

HRID 2171028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2171028
[NH2:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[CH2:5][CH2:4]1.C(N(CC)CC)C.[C:35](Cl)(=[O:40])[O:36][CH:37]([CH3:39])[CH3:38]>ClCCl>[CH:37]([O:36][C:35](=[O:40])[NH:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:19]=3[CH2:20][CH2:21][C:22]4=[O:27])=[CH:10][CH:11]=[C:12]([O:16][CH3:17])[C:13]=2[O:14][CH3:15])[CH2:4][CH2:5]1)([CH3:39])[CH3:38]

Komponenten

5

Edukt 3

HCID 7917Isopropyl chloroformateHCID 8471TriethylamineHCID 71279377HCID 71279377, Verbindung2×

Produkt 1

HCID 54577375HCID 54577375, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirring solution of 4-[2-(1-Aminomethyl-cyclopropylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 182) (150 mg, 0.272 mmol) in dichloromethane (10 mL), were added triethylamine (0.082 g, 0.811 mmol) and isopropyl carbonochloridate (66 mg, 0.544 mmol) and the resultant reaction mixture was subjected to the conditions used in the preparation of Compound 183 to afford the title compound as a solid.

Aufarbeitung

  1. customthe resultant reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-d076bc14063745238d71d1de16ba87e7
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051290B2

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