3,5-Dimethylphenylboronic acid → HCID 59313068, Verbindung
Reaktionsgleichung
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[N:17]=[C:16]([NH2:18])[C:15]([N+:19]([O-:21])=[O:20])=[CH:14][CH:13]=2)[N:5]2[CH:22]=[C:23]([CH3:25])[N:24]=[C:4]2[CH:3]=1.[CH3:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[C:31]([CH3:33])[CH:32]=1>>[CH3:26][C:27]1[CH:28]=[C:29]([C:2]2[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]3[N:17]=[C:16]([NH2:18])[C:15]([N+:19]([O-:21])=[O:20])=[CH:14][CH:13]=3)[N:5]3[CH:22]=[C:23]([CH3:25])[N:24]=[C:4]3[CH:3]=2)[CH:30]=[C:31]([CH3:33])[CH:32]=1Komponenten
3
Versuchsvorschrift
In analogy to the procedure described for Example 7, 4 mg (3% of theory) of the product are obtained starting from 120 mg (0.32 mmol) of N6-{2-[(7-chloro-2-methylimidazo[1,2-c]pyrimidin-5-yl)amino]ethyl}-3-nitropyridine-2,6-diamine (Example 31A) by coupling with 57 mg (0.38 mmol) of (3,5-dimethylphenyl)boronic acid and subsequent purification by preparative HPLC.
Aufarbeitung
- customare obtained
Quellen und Nachweise
- ORD-Eintrag
- ord-943c5a2506e5438e90a4c0454405ccb6