Trifluoroacetic acid → 5-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

HRID 2172589Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2172589
[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:33])[CH3:32])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[O:8]CC1C=CC(OC)=CC=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:32])[CH3:33])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[OH:8]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 866862845-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one

Produkt 1

HCID 1363878065-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution 5-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one from Step I (661 mg, 1.31 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (1 mL). The solution was stirred at ambient temperature for one hour. Concentration in vacuo provided the title compound as a yellow solid (assume theoretical yield). MS (M+H): 387

Aufarbeitung

  1. concentrationConcentration in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0ddde50e769a4f06b743f927d14a6100
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09056110B2

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